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Micro et Nanomédecines translationnelles

Welcome on MINT homepage

The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, mRNA, etc.) and/or imaging probes.

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Recently published



Nanomedicines via the pulmonary route: a promising strategy to reach the target?

Mélina Guerin & Elise Lepeltier

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Investigating the Reactivity of a Novel Methacrylic Transmer in Solution RAFT-SCVP and Its Impact on the Structure of the Resulting Hyperbranched Polymers

Typhaine Despres, Tiffaine Fabre, Samuel Legeay, Guillaume Bastiat, Franck D’Agosto, Muriel Lansalot, Morwenna S. M. Pearson-Long, Sandie Piogé, and Sagrario Pascual

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MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

Hussein H Genedy , Paul Humbert Bilel Laoulaou, Brian Le Moal , Marion Fusellier Catherine Passirani , Catherine Le Visage , Jérôme Guicheux Élise Lepeltier  & Johann Clouet 

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Caliper, contrast enhanced-ultrasound or laser speckle contrast imaging: Techniques to follow mice melanoma growth

Adélie Mellinger, Jeanne Hersant, Clara Bourreau, Simon Lecoq, Eva Deveze, Nicolas Clere & Samir Henni

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Electrochemical Nucleic Acid Biosensor on a Microfluidic Chip to Understand the Coupling between Electrochemistry and Microfluidics

Marie-Charlotte Horny, MartinaFreisa, ClairePoujouly, Pedro Gonzalez-Losada, Jeremy Le Gall, Thi-Hong-Nhung Dinh, David Bouville, Isabelle Le Potier,Antoine Pallandre and Jean Gamby

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Diversely substituted poly(N-vinyl amide) derivates towards non-toxic, stealth and pH-responsive lipid nanocapsules

F. Toussaint, E. Lepeltier, F. Franconi, V Pautu, C Jérôme, C. Passirani & A Debuigne

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Investigating the functionalization of liposomes with NFL-TBS. 40-63 peptides as a promising drug delivery system

M-A Jourdain, A. Dupont, N. Lautram & J. eyer 

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The use of liposomes functionalized with the NFL-TBS.40–63 peptide as a targeting agent to cross the in vitro blood–brain barrier and target glioblastoma cells

Adélie Mellinger, Larissa J. Lubitz, Claire Gazaille, Gero Leneweit, Guillaume Bastiat, Claire Lépinoux-Chambaud & Joel Eyer

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Evidence of residual micellar structures in a lipid nanocapsule dispersion. A multi-technique approach

Emilie Roger, Florence Franconi, Tran Anh Thu Do, Carl Simonsson, Benjamin Siegler, Rodolphe Perrot, Patrick Saulnier, Jean-Christophe Gimel

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Contact angle of ethanol, water, and their mixtures on stainless steel surfaces in dense carbon dioxide
Aymeric Fabien, Guillaume Lefebvre, Elisabeth Badens, Brice Calvignac, Damien Chaudanson, Alain Ranguis, Christelle Crampon

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3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
J. Bronsard, C. Savary, J. Massart, R. Viel, L. Moutaux, D. Catheline, V. Rioux, B. Clement , A. Corlu , B. Fromenty , P.J. Ferron

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Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition

Vincent Lebreton, Samuel Legeay, Anastasiia Vasylaki, Fredéric Lagarce, Patrick Saulnier

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Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel

Claire Gazaille , Elia Bozzato, Neda Madadian-Bozorg, Adélie MellingerMarion Sicot, Umer Farooq, Patrick SaulnierJoël Eyer, Véronique Préat, Nicolas Bertrand, Guillaume Bastiat 

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Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Mickael Lehr & Claudio J Salomon

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Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies

Cécile DoualleJulien GoujuYousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick SaulnierJoël Eyer, Franck Letournel


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Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure

Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani

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Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

Clara Bourreau, Lucas Treps, Sébastien Faure, Delphine Fradin & nicolas Clère

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Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer

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Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells
Imen Graiet,
Hiba Hamdi, Salwa Abid-Essefi & J Eyer

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Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique

Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P,  Lagarce F, Gattacceca F, Legeay S &  Roger E

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Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules

A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer

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Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells.

Griveau A, Arib C, Spadavecchia J, Eyer J.

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Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma

Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C

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Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications

Arib C, Griveau A, Eyer J & Spadavecchia J

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Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics

Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O  & Calvignac B

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