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Micro et Nanomédecines translationnelles

Welcome on MINT homepage

The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, etc.) and/or imaging probes.

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Academic training


Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D


European Mundus Joint master Degree " Nanomedicine for drug delivery"

Recently published



Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition

Vincent Lebreton, Samuel Legeay, Anastasiia Vasylaki, Fredéric Lagarce, Patrick Saulnier

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Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel

Claire Gazaille , Elia Bozzato, Neda Madadian-Bozorg, Adélie MellingerMarion Sicot, Umer Farooq, Patrick SaulnierJoël Eyer, Véronique Préat, Nicolas Bertrand, Guillaume Bastiat 

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Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Mickael Lehr & Claudio J Salomon

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Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies

Cécile DoualleJulien GoujuYousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick SaulnierJoël Eyer, Franck Letournel


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Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure

Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani

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Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

Clara Bourreau, Lucas Treps, Sébastien Faure, Delphine Fradin & nicolas Clère

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Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer

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Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells
Imen Graiet,
Hiba Hamdi, Salwa Abid-Essefi & J Eyer

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Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique

Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P,  Lagarce F, Gattacceca F, Legeay S &  Roger E

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Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules

A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer

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Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells.

Griveau A, Arib C, Spadavecchia J, Eyer J.

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Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma

Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C

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Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications

Arib C, Griveau A, Eyer J & Spadavecchia J

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Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics

Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O  & Calvignac B

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Granting agencies