Welcome on MINT homepage

The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, etc.) and/or imaging probes.

News

3 PhDs fellows are joining MINT

We are delighted to welcome 3 PhDs fellows

CARNANOMED : Characterization of nanomedicines

The November 6, 2023

These two equipments are essential for the production of nanomedicines, because they enable us to carry out qualitative and quantitative analyses.

Thès’art : quand les sujets de thèse rencontrent la bande dessinée - contribution de Jaspe CHEN

The November 6, 2023

Jaspe CHEN, doctorante au laboratoire a participé à ce projet porté par Terre des Sciences et l’Université d’Angers avec le soutien financier de la DRARI des Pays de la Loire dans le cadre de la Fête de la Science.

Academic training

Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D

European Mundus Joint master Degree " Nanomedicine for drug delivery"

Recently published

		Evidence of residual micellar structures in a lipid nanocapsule dispersion. A multi-technique approach Emilie Roger, Florence Franconi, Tran Anh Thu Do, Carl Simonsson, Benjamin Siegler, Rodolphe Perrot, Patrick Saulnier, Jean-Christophe Gimel link to publisher link to intranet
		Contact angle of ethanol, water, and their mixtures on stainless steel surfaces in dense carbon dioxide Aymeric Fabien, Guillaume Lefebvre, Elisabeth Badens, Brice Calvignac, Damien Chaudanson, Alain Ranguis, Christelle Crampon link to publisher link to intranet
		3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments J. Bronsard, C. Savary, J. Massart, R. Viel, L. Moutaux, D. Catheline, V. Rioux, B. Clement , A. Corlu , B. Fromenty , P.J. Ferron link to publisher link to intranet
		Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition Vincent Lebreton, Samuel Legeay, Anastasiia Vasylaki, Fredéric Lagarce, Patrick Saulnier link to publisher link to intranet
		Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel Claire Gazaille, Elia Bozzato, Neda Madadian-Bozorg, Adélie Mellinger, Marion Sicot, Umer Farooq, Patrick Saulnier, Joël Eyer, Véronique Préat, Nicolas Bertrand, Guillaume Bastiat link to publisher link to intranet
		Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Mickael Lehr & Claudio J Salomon link to publisher link to intranet
		Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies Cécile Doualle, Julien Gouju, Yousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick Saulnier, Joël Eyer, Franck Letournel link to publisher link to intranet
		Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani link to publisher link to intranet
		Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies Clara Bourreau, Lucas Treps, Sébastien Faure, Delphine Fradin & nicolas Clère link to publisher link to intranet
		Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer link to publisher link to intranet
		Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells Imen Graiet, Hiba Hamdi, Salwa Abid-Essefi & J Eyer link to publisher link to intranet
		Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P, Lagarce F, Gattacceca F, Legeay S & Roger E link to publisher link to intranet
		Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer link to publisher link to intranet
		Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells. Griveau A, Arib C, Spadavecchia J, Eyer J. link to publisher link to intranet
		Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C link to publisher link to intranet
		Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications Arib C, Griveau A, Eyer J & Spadavecchia J link to publisher link to intranet full text
		Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O & Calvignac B link to publisher link to intranet

Granting agencies