Welcome on MINT homepage
The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, etc.) and/or imaging probes.
News
Academic training
Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D
European Mundus Joint master Degree " Nanomedicine for drug delivery"
Recently published
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Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies Cécile Doualle, Julien Gouju, Yousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick Saulnier, Joël Eyer, Franck Letournel
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Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani |
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Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer |
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Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells |
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Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P, Lagarce F, Gattacceca F, Legeay S & Roger E |
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Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer |
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Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells. Griveau A, Arib C, Spadavecchia J, Eyer J. |
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Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C |
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Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications Arib C, Griveau A, Eyer J & Spadavecchia J |
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Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O & Calvignac B |
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FRET as the tool for in vivo nanomedicine tracking Kaeokhamloed N, Legeay s & Roger E |
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Lipid nanocapsules for intracellular delivery of microRNA: A first step towards intervertebral disc degeneration therapy Le Moal B, Lepeltier E, rouleau D, Le Visage C, Benoit JP, Passirani C, Guicheux J, Fusellier M & Clouet J |
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Can magnetization transfer magnetic resonance imaging help for the follow-up of synthetic hernia composite meshes fate? A pilot study Franconi F, Lefranc O, Radlovic A & Lemaire L |
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Tailoring PEGylated nanoparticle surface modulates inflammatory response in vascular endothelial cells Therani SF, Rabanel J-M, Legeay S, Cayon J, Riou J, Saulnier P, Marleau S, Roullin VG, Hildgen P & Bastiat G |
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DDS for oral administration of antimicrobial peptides: Promising tools to treat infectious diseases Deshayes C, Arafath MD, Apaire-Marchais V & Roger E |
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Cell penetrating peptide decorated magnetic porous silicon nanorods for glioblastoma therapy Chaix A, Griveau A, Defforge T, Grimal V, Le Borgne B, Gautier G and Eyer J |
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Impact of anti-PDGRFa antibody surface functionnalization on LNC uptake by oligodendrocyte progenitor cells Labrak Y, Heurtault B, Frisch B, Saulnier P, Lepeltier E, Miron VE, Muccioli GG & Des Rieux A link to publisher link to intranet
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Green Nanotechnology - An innovative pathway towards biocompatible and medically relevant gold nanoparticles Thipe VG, Karikachery AR, Cakilkaya P, Farooq U,Genedy HH, Kaeokhamloed N, Phan DH, Rezwan R, Tezcan G, Roger E, Katti KV. |
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Interfacial tension of ethanol, water, and their mixtures in high pressure Fabien A, Lefebvre G, Calvignac B, Legout P, Badens E &Crampon C |
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Epoxiconazole profoundly alters rat brain and properties of neural stem cells Hamdi H, Graiet I, Abid-Essefi S & Eyer J link to publisher link to intranet
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Modulating undruggable targets to overcome cancer therapy resistance Passirani C, Vessières A, La Regina G, Link W & Silvestri R |
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Stability of a high-concentrated aqueous solution of idarubicin stored in a polypropylene syringe for transarterial chemoembolization Bourcier B, Lagarce F & Lebreton V |
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| Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes.
Baroud M, Lepeltier E, El-Makhour Y, Lautram N, Bejaud J, Thepot S & Duval O |
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The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery Baroud M., Lepeltier E., Thepot S., El-Makhoure Y. & Duval O. |
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Organic nanoparticle tracking during pharmacokinetic studies Bonnet S., Elfatairi R., Franconi F., Roger E. & Legeay S. |
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Local delivery and glioblastoma: Why not combining sustained release and targeting? Gazaille C.*, Sicot M.*, Saulnier P., Eyer J & Bastiat G |
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Microbiota and nanoparticles: Description and interactions Ladaycia A, Passirani C & Lepeltier E |
