Self-assemblies of cell-penetrating peptides and ferrocifen : an innovative platform for lung cancer treatment

The November 4, 2019

Titre :

Self-assemblies of cell-penetrating peptides and ferrocifen : an innovative platform for lung cancer treatment

Directeur de Thèse: Pr Catherine Passirani

Co-directrice de thèse : Dr Elise Lepeltier

Abstract: The aim of this project was to develop a new type of nanoparticle in order to transport ferrocifen molecules, combining three different strategies: the use of cell-penetrating peptides (CPPs), prodrug and their potential self-association. The synthesis of conjugates (CPP-p54) consisting of two different types of cell-penetrating peptides Argn-p54 (n=6 to 9) and RLW-p54, their self-assembly in water and the complete characterization of the self-assemblies were carried out, by highlighting the importance of the methods used to characterize the suspension. In vitro studies were also performed on healthy cell line and lung cancer cells showing an improvement in biological activity by a factor 9.

Key words: Cell penetrating peptide; Ferrocifens; auto-assemblies; lung cancer.