Prof Kattesh V. Katti lecture

The October 1, 2019

Pr K. V. Katti  (Curators’ Professor of Radiology and Physics, Director, Institute of Green Nanotechnology, University of Missouri Hospitals and Clinics, One Hospital Drive; University of Missouri;Columbia, Missouri 65212, USA), will give a lecture on october  1, 2019, 17:00 at Angers University, Campus Santé, site Daviers.

Biographic note:

Professor Kattesh V. Katti recognized globally as the ‘Father of Green Nanotechnology’ is a leader in the interconnecting fields of chemistry, radiopharmaceutical sciences, nanotechnology/green nanotechnology and nanomedicine for biomedical applications, specifically for molecular imaging and therapy of living subjects. The impact of Dr. Katti’s work is widespread, as his pioneering discoveries and strategies, originally developed in his laboratory in Bioconjugate Chemistry and Nanomedicine, and Green Nanotechnological tools, are used in many laboratories, industries and hospitals around the world. His contributions in nano and green nanotechnologies have already created a transformative progress in nanomedicine by aiding molecular imaging to help diagnose and manage therapy all at the cellular levels. Dr. Katti is the first scientist to provide experimental proof for the selective tumor uptake of phytochemical encapsulated gold nanoparticles through ‘Green Nanotechnology’. Dr. Katti’s medical research has transformed Ayurvedic medicine from a holistic medical field bogged down in alchemy and mysticism into scientifically and universally acceptable field of Nano Ayurvedic Medicine. This new medical modality makes use of scientifically verified principles to de velop herbs/phytochemical encapsulated nanoparticles to provide well defined doses to target cancer cells resulting in evidence based predictability of treatment outcomes and above all 100% reproducibility of various therapeutic formulations. Dr. Katti’s ground breaking discoveries in green nanotechnology where he has demonstrated that biocompatible nanoparticles can be produced without the intervention of any toxic chemicals through phytochemicals of high antioxidant capacities and tumor receptor specificities have created a new generation of molecular imaging and therapeutic and theranostic nanoceuticals. Myriad of such approaches developed by Dr. Katti are providing a strong scientific basis to various forms of holistic herbal medicine practiced in Asia, Africa and other parts of the world. For his pioneering efforts in Nanomedicine, Green Nanotechnology and Nano Ayurvedic medicine, Dr. Katti has been awarded a number of international awards and citations which include: European Union Guest Professor of Green Nanotechnology (2018), Winner of the 2016 'Person of the Year in Science' award, 2016 RMIT Foundation Fellowship Award, International Hevesy Medal Award (2015) for excellence in Nuclear Sciences —the highest international prize in Nuclear Sciences, ;Elected to the fellowship of the National Academy of Inventors (2015) recognizing the discovery of ‘Katti Peptides’ - a group of peptides he discovered in the 90s which have found biomedical and nanotechnological applications. Dr. Katti is also recognized as ‘One of the 25 Most Influential Scientists In Molecular Imaging in the World’— a prestigious award by RT Image, the ‘Father of Green Nanotechnology’ citation by the Nobel Prize Winner Norman Borlaug, Gauss Professorship —Hall of Fame from the Gottingen Academy of Sciences, Germany, ‘Outstanding Scientists Fellows’ award and his election as a Fellow of the coveted Academy of Science, St Louis— one of the oldest scientific academies of the world and many more. Dr. Katti was elected as a fellow of the American Association for the Advancement of Science (AAAS). State of Missouri, USA, has given the state’s highest civilian award as an ‘Outstanding Missourian’—the first such award by an immigrant American. His unprecedented discoveries of the production of tumor specific gold nanoparticles through 100% green processes have been cited as the Editor’s choice in Nature, Future Medicine, in Science (AAAS), in Popular Science, by the Discovery Channel and have been highlighted in scientific/medical programs of the British Broadcasting Corporation (BBC, London).

Professor Katti has published over 300 publications/reviews/book chapters/patents and is the principal inventor onover 50 patents and over 150 inventions. He is the executive/chief  editor/member of editorial boards of numerous peer reviewed journals of high repute. Professor Katti has delivered over 500 invited/Plenary/Inaugural lectures in over 35 contries

 

Lecture abstract:

This lecture presents details on career opportunities in biomedical sciences for students pursuing higher education in the United States. Students can choose to complete higher education at the Masters or PhD levels in a variety of areas of biomedical sciences including in cutting edge areas of nanoscience, nanomedicine and green nanotechnology. Biomedical aspects of oncology, antibiotics, neurological sciences, brain research and psychological sciences also offer a wide range of career opportunities. Higher education in the US encompasses both formal education and experimental work. Normally, dissertation writing will be the requirement for completing both the Masters level and PhD level programs.

Nanomedicine is an example of a cutting research field where we have excelled with global reputation at the Institute of Green Nanotechnology within the Medical School, University of Missouri, Columbia, USA. Cancer continues to be a major public health problem worldwide and there were an estimated 18 million cancer cases around the world in 2018 of which 9.5 million patients died. By 2040, the global burden is expected to grow to 27.5 million new cancer cases and 16.3 million cancer deaths simply due to the growth and aging of the population. The future burden will probably be even larger due to increasing prevalence of factors that increase risk, such as smoking, unhealthy diet, physical inactivity, and fewer childbirths, especially in economically transitioning countries. A number of new therapeutic interventions to combat various forms of human cancer have been developed over the last several decades. However, cures and lifesaving arrestation of this disease have been rare because tumors bear innate characteristics to become resistant to various forms of treatment. It is becoming increasingly clear that various chemotherapeutic, immunotherapeutic and radiation-based treatment modalities activate NF-κB transcription factors, which are responsible for triggering various pro-tumorigenic cascade of processes within the tumor microenvironment. Tumor progression and the evasion of systemic immune surveillance are all dictated by significantly high levels of various immunosuppressive factors, such as IL-10, IL-6, and TGF-β. Tumor progression is further catalyzed by the immune cells, including regulatory T cells, dendritic cells, MDSCs and TAMs, which are known to express a low level of MHC class I molecules within the tumor microenvironment. Most cancer drugs, in current use which belong to specific targeted or cytotoxic agents, rely on “one gene, one target, one disease” approach despite the fact that cancer is a very complicated multi-target and multi-gene defective disease. However, several examples of phytochemical-based therapeutic approaches have shown the power of cocktail of phytochemicals in traditional Indian Ayurvedic (Chinese and African) medicines to be multi targeted by enhancing the CD4⁺/CD8⁺ T cell ratio in the tumor microenvironment. Herbal-based Ayurvedic medicine are also known to reeducate the macrophage by promoting the M1 differentiation of TAM, suggesting the poly-pharmacological and poly-targeted nature of phyto agents

 

This lecture will discuss career opportunities on the application of innovative Green Nanotechnology discoveries, made in Dr. Katti’s laboratory, to develop novel nanomedicine agents derived from combination of tumor specific phytochemicals encapsulated onto biocompatible gold nanoparticles. The longstanding objective of this approach focuses on providing credible scientific rationale to phytochemical-based herbal (Ayurvedic) nanomedicine—all aimed at developing new Precision Medicine modality referred to as ‘Nano-Ayurvedic Medicine. Green Nanotechnology also allows the development of reproducible formulations of herbal and classical Ayurvedic Nanomedicines, thus providing a pathway for clinical trials for internal/external validity, to allow the safety and efficacy of specific herbal medicines in a more accurate and scientifically verifiable way. This lecture will discuss details on how green nanotechnology can be used to develop small-molecule phytochemical(s)-functionalized gold nanoparticles to simultaneously achieve: (i) Inhibition of NfkB activation; (ii) Targeting TAMs; and (iii) Inhibition of TNF-α induced p65 phosphorylation; and concomitant immunomodulatory therapeutic action. Details on the new invention of a medical modality, referred to as ‘Nano-Ayurvedic Medicine’, recently approved by the US Patents and Trade Marks Office will be presented. The lecture will also highlight the importance of clinical translation in medical research through recent results from human clinical trials on cancer patients of Nano-Ayurvedic Nanomedicine drugs derived through green nanotechnology. The overall importance of green nanotechnology in graduate education and toward developing nanomedicine agents for use in oncology and antibiotics with specific examples of recently commercialized pharmaceuticals would be presented. In addition to results on the frontiers of nanomedicine, this lecture will present outstanding opportunities for prospective French and International students for graduate education in the United States of America.