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The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, mRNA, etc.) and/or imaging probes.

News

Women in science - Lea DAOUD presents her PhD

Léa DAOUD presents her PhD work to schoolgirl

Habilitation à diriger des recherches

Oksana Krupka retraces her scientific career, which began with a thesis at Kyiv's Taras Shevchenko University

A gel of nanoparticles to prevent hyperplasia

Together with Dr. Joohee Park, maturation engineer at the Satt and Abhinandan Nandrajog first-year PhD student, Dr. Guillaume Bastiat develops a gel against hyperplasia

Recently published

		Self-assemblies of cell-penetrating peptides and ferrocifens: design and biological evaluation of an innovative platform for lung cancer treatment Léna Guyon, Abdallah Ladaycia, Agnese Bosio, Laurent Lemaire, Florence Franconia, Bénédicte Lelièvre, Nolwenn Lautram, Pascal Pigeon, Gérard Jaouen, Catherine Passirani, Elise Lepeltier link to publisher link to intranet
		One-Step Synthesis of Poly(2-alkyl-2-oxazoline)-Coated Gold Nanospheres: A Greener Approach for Biomedical Uses Léa Daoud, Stéphane Hoang, Alexia Milin-Moguerou, Joël Eyer, Tony Breton, Véronique Montembault, Laurent Fontaine, Catherine Passirani, Patrick Saulnier, and Oksana Krupka link to publisher link to intranet
		Focus on the importance of the process parameters: temperature cycles and “shock” water addition during the phase inversion process for the formulation of lipid nanoparticles Claire Gazaille, Sonia Pîgles, Krist´of Apr´o , Laura Ruesche , Aouatef Foudi , Adélie Mellinger , Benjamin Siegler , Joel Eyer , Laurent Lemaire , Patrick Saulnier , Florence Franconi , Guillaume Bastiat link to publisher link to intranet
		Thymoquinone loaded lipid nanocapsule dispersion: two methods of preparation, characterization and in vitro evaluations for oral administration Mouna Selmi, Amine Trabelsi, Nolwenn Lautram, David Dallerac, Guillaume Lefebvre, Leila Chekir Ghedira & Emilie Roger link to publisher link to intranet
		Internalization and mechanisms of toxicity of lipid nanocapsules in HepG2 and HepaRG hepatoma cells upon acute and chronic exposures Flavien Delaporte, Emilie Roger, Jérome Bejaud, Pascal Loyer, Frédéric Lagarce, Camille C. Savary link to publisher link to intranet
		Nanomedicines via the pulmonary route: a promising strategy to reach the target? Mélina Guerin & Elise Lepeltier link to publisher link to intranet
		Investigating the Reactivity of a Novel Methacrylic Transmer in Solution RAFT-SCVP and Its Impact on the Structure of the Resulting Hyperbranched Polymers Typhaine Despres, Tiffaine Fabre, Samuel Legeay, Guillaume Bastiat, Franck D’Agosto, Muriel Lansalot, Morwenna S. M. Pearson-Long, Sandie Piogé, and Sagrario Pascual link to publisher link to intranet
		MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration Hussein H Genedy, Paul Humbert, Bilel Laoulaou, Brian Le Moal, Marion Fusellier, Catherine Passirani, Catherine Le Visage, Jérôme Guicheux, Élise Lepeltier & Johann Clouet link to publisher link to intranet
		Caliper, contrast enhanced-ultrasound or laser speckle contrast imaging: Techniques to follow mice melanoma growth Adélie Mellinger, Jeanne Hersant, Clara Bourreau, Simon Lecoq, Eva Deveze, Nicolas Clere & Samir Henni link to publisher link to intranet
		Electrochemical Nucleic Acid Biosensor on a Microfluidic Chip to Understand the Coupling between Electrochemistry and Microfluidics Marie-Charlotte Horny, MartinaFreisa, ClairePoujouly, Pedro Gonzalez-Losada, Jeremy Le Gall, Thi-Hong-Nhung Dinh, David Bouville, Isabelle Le Potier,Antoine Pallandre and Jean Gamby link to publisher link to intranet
		Diversely substituted poly(N-vinyl amide) derivates towards non-toxic, stealth and pH-responsive lipid nanocapsules F. Toussaint, E. Lepeltier, F. Franconi, V Pautu, C Jérôme, C. Passirani & A Debuigne link to publisher link to intranet
		Investigating the functionalization of liposomes with NFL-TBS. 40-63 peptides as a promising drug delivery system M-A Jourdain, A. Dupont, N. Lautram & J. eyer link to publisher link to intranet
		The use of liposomes functionalized with the NFL-TBS.40–63 peptide as a targeting agent to cross the in vitro blood–brain barrier and target glioblastoma cells Adélie Mellinger, Larissa J. Lubitz, Claire Gazaille, Gero Leneweit, Guillaume Bastiat, Claire Lépinoux-Chambaud & Joel Eyer link to publisher link to intranet
		Evidence of residual micellar structures in a lipid nanocapsule dispersion. A multi-technique approach Emilie Roger, Florence Franconi, Tran Anh Thu Do, Carl Simonsson, Benjamin Siegler, Rodolphe Perrot, Patrick Saulnier, Jean-Christophe Gimel link to publisher link to intranet
		Contact angle of ethanol, water, and their mixtures on stainless steel surfaces in dense carbon dioxide Aymeric Fabien, Guillaume Lefebvre, Elisabeth Badens, Brice Calvignac, Damien Chaudanson, Alain Ranguis, Christelle Crampon link to publisher link to intranet
		3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments J. Bronsard, C. Savary, J. Massart, R. Viel, L. Moutaux, D. Catheline, V. Rioux, B. Clement , A. Corlu , B. Fromenty , P.J. Ferron link to publisher link to intranet
		Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition Vincent Lebreton, Samuel Legeay, Anastasiia Vasylaki, Fredéric Lagarce, Patrick Saulnier link to publisher link to intranet
		Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel Claire Gazaille, Elia Bozzato, Neda Madadian-Bozorg, Adélie Mellinger, Marion Sicot, Umer Farooq, Patrick Saulnier, Joël Eyer, Véronique Préat, Nicolas Bertrand, Guillaume Bastiat link to publisher link to intranet
		Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Mickael Lehr & Claudio J Salomon link to publisher link to intranet
		Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies Cécile Doualle, Julien Gouju, Yousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick Saulnier, Joël Eyer, Franck Letournel link to publisher link to intranet
		Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani link to publisher link to intranet
		Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies Clara Bourreau, Lucas Treps, Sébastien Faure, Delphine Fradin & nicolas Clère link to publisher link to intranet
		Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer link to publisher link to intranet
		Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells Imen Graiet, Hiba Hamdi, Salwa Abid-Essefi & J Eyer link to publisher link to intranet
		Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P, Lagarce F, Gattacceca F, Legeay S & Roger E link to publisher link to intranet
		Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer link to publisher link to intranet
		Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells. Griveau A, Arib C, Spadavecchia J, Eyer J. link to publisher link to intranet
		Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C link to publisher link to intranet
		Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications Arib C, Griveau A, Eyer J & Spadavecchia J link to publisher link to intranet full text
		Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O & Calvignac B link to publisher link to intranet

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