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Micro et Nanomédecines Translationnelles

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    Welcome on MINT homepage

    The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and inferfaces physio-chemistry; galenic chemistry for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, etc.) and/or imaging probes.


    Mme Léna GUYON - Nouvelle docteure de l'Université d'Angers

    Auto-assemblages constitués de peptides pénétrants et de ferrocifène : une plateforme innovante pour le traitement du cancer du poumon : Soutenance de Thèse de Mme Léna GUYON

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    DISCODOG : MINT will take part to this project under RMes Lead

    DISCODOG project led by STEP team....

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    Mme Emilie ROGER, nouvelle HDR de l'Université D'Angers

    Développement de nouveaux systèmes de délivrance de principe actif adaptés à leur voie d’administration

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    NATEMOC : An ANR funded project for Pr Catherine Passirani Research

    This research project directed by Pr Catherine Passirani is granted by the French Research Agency (ANR) for the coming 4 years.

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    CARBOMIC: An ANR funded project for Dr Brice Calvignac Research

    This research project directed by Dr Brice Calvignac is granted by the French Research Agency (ANR) for the coming 4 years.

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    Recently published

    Do albendazole-loaded lipid nanocapsules enhance the bioavailability of albendazole in the brain of healthy mice?

    Fabbri J, Espinosa JP, Pensel P,1 Medici SK, Gamboa GU, Benoit JP, Elissondo MC.


    Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and in vivo biodistribution improvements

    P. Resnier, E. Lepeltier, A. L. Emina, N. Galopin, J. Bejaud, S. David, C Ballet, T. Benvegnu, F. Pecorari, I. Chourpa, J-P. Benoit and C. Passirani



    Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs

    Cadete A, Olivera A, Besev M, Dhal PK, Gonçalves L, Almeida AJ, Bastiat G, Benoit JP, de la Fuente M, Garcia-Fuentes M, Alonso MJ, Torres D.



    A comparison of different strategies for antimicrobial peptides incorporation onto/into lipid nanocapsules.

    Matougui N, Groo AC, Umerska A, Cassisa V, Saulnier P.


    Characterization of the in vitro, ex vivo, and in vivo Efficacy of the Antimicrobial Peptide DPK-060 Used for Topical Treatment.

    Håkansson J, Ringstad L, Umerska A, Johansson J, Andersson T, Boge L, Rozenbaum RT, Sharma PK, Tollbäck P, Björn C, Saulnier P, Mahlapuu M.

    Nanoencapsulated deltamethrin as synergistic agent potentiates insecticide effect of indoxacarb through an unusual neuronal calcium-dependent mechanism

    Caballero JP, Murillo L, List O, Bastiat G, Flochlay-Sigognault A, Gerino F, Lefrancois C, Lautram N, Lapied B, Apaire-Marchais V.


    The NFL-TBS.40-63 peptide targets and kills glioblastoma stem cells derived from human patients and also targets nanocapsules into these cells

    Lépinoux-Chambaud C, Eyer J

    Cytotoxic and genotoxic effects of epoxiconazole on F98 glioma cellsHamdi H, Abid-Essefi S, Eyer J


    Lipid nanocapsules as in vivo oxygen sensors using magnetic resonance imaging

    Nel J, Franconi F, Joudiou N, Saulnier P, Gallez B, Lemaire L


    UV-triggered photoinseertion of contast agent onto polymer surfaces for in vivo MRI-visible medical devices

    Schultz A, Lemaire L, Bethry A, Allegre L, Cardoso M, Bernex F, Franconi F, Goz-bac C, Taillades H, Garric X, Nottelet B


    Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity

    Briot T., Roger E., Bou Haidar N., Bejaud J., Lautram N., Guillet C., Thépot S., Legeay S. & Lagarce F


    The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

    Laura Pinton, Elena Masetto, Marina Vettore, Samantha Solito, Sara Magri, Marta D’Andolfi, Paola Del Bianco, Giovanna Lollo, Jean-Pierre Benoit, Hideho Okada, Aaron Diaz, Alessandro Della Puppa and Susanna Mandruzzato

    Albendazole-lipid nanocapsules: Optimization, characterization and chemoprophylactic efficacy in mice infected with Echinococcus granulosus.

    Ullio Gamboa GV, Pensel PE, Elissondo MC, Sanchez Bruni SF, Benoit JP, Palma SD, Allemandi DA.


    Controlled Anchoring of Iron-Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core@Shell Organic-Inorganic Nanocomposites for Magneto-Scaffolds

    Awada Hussein, Samad Assala Al, Laurencin Danielle, Gilbert Ryan J, Dumail Xavier, jundi Ayman El, Bethry Audrey, Pomrenke Rebecca, Johnson Christopher, Lemaire Laurent, Franconi Florence, Félix Gautier, Larionova Joulia, Guari Yannick, Nottelet Benjamin


    Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment


    Bastiancich Chiara, Bozzato Elia, Luyten Urszula, Danhier Fabienne, Bastiat Guillaume, Préat Véronique


    Magnetite- and Iodine-Containing Nanoemulsion as a Dual Modal Contrast Agent for X-ray/Magnetic Resonance Imaging


    Wallyn justine, Anton Nicolas, Mertz Damien, Begin-Colin Sylvie, Pertron Francis, Serra A. Christophe, Franconi Florence, Lemaire Laurent, Chiper Manuela, Libouban Hélène, Messaddeq N, Anton Halina & Vandamme Thierry H.



    Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for glioma therapy: in vitro screening of critical parameters


    Aparicio-Blanco Juan, Sebastián Víctor, Benoît Jean-Pierre, Torres-Suárez Ana


    Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry


    Nel Janske, Desmet Céline M, Driesschaert Benoit, Saulnier Patrick, Lemaire Laurent, Gallez Bernard


    Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo


    Rozenbaum René T, Su Linzhu, Umerska Anita-Monika, Eveillard Matthieu, Håkansson Joakim, Mahlapuu Margit, Huang Fan Liu Jianfeng, Zhang Zhenkun, Shi Linqi, van der Mei Henny C, Bussche Henk J, Sharma Prashant K


    Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide.


    Groo AC, Matougui N, Umerska A, Saulnier P.


    Melanoma tumour vasculature heterogeneity: from mice models to human.


    Pautu V, Mellinger A, Resnier P, Lepeltier E, Martin L, Boussemart L, Letournel F, Passirani C, Clere N.












    pilote de synthèse en milieu CO2 supercritiqueLaboratoire de culture cellulaireAnalyse thermiqueGranulométrieMesure tension interfacialeAnalyse LCMSMSPhoto_Unité_INSERM 1066 CNRS 6021Balance de Langmuir

    Academic training

    Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D

    European Master in nanomedecine & phamaceutical innovation


    Institut de Biologie en Santé
    (3ème étage)
    Plateau des Capucins

    Coordonnées GPS

    de la gare,
    direction AVRILLÉ-ARDENNE,
    arrêt CAPUCINS

    Granting agencies