Welcome on MINT homepage

The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, etc.) and/or imaging probes.

News

4th NANOMED EMJMD's workshop

This International event is an opportunity for the NANOMED students and young researchers to present and share their research work with highly recognized specialists in a human-sized scientific conference. This 4th Edition will be dedicated to Translational Nanomedicines and will be held in Angers from July 7-9, 2021

Soutenance de Thèse de Mr Pierre LEGOUT

The May 19, 2021

Synthèse de copolymères fonctionnels amphiphiles appliqués à la cristallisation de particules de carbonate de calcium en milieu CO2 supercritique par un procédé d'émulsification continu et éco-responsable

Cover page of drug delivery and translational research

April 2021 cover page of drug delivery and translational research for this collaborative work with Pr. Maria Blanco-Prieto from Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra,Pamplona, Spain

Academic training

Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D

European Master in nanomedecine & phamaceutical innovation

Recently published

		NMR diffusometry: A new perspective for nanomedicine exploration Franconi F, Lemaire L, Gimel JC, Bonnet S, Saulnier P link to publisher link to intranet
		Magnetic and Highly Luminescent Heterostructures of Gd³⁺/ZnO Conjugated to GCIS/ZnS Quantum Dots for Multimodal Imaging Lallo da Silva B, Lemaire L, Benoit JP, Hediger Borges F, Rocha Gonçalves R, Amantino CF, Primo FL and Aparecida Chiavacci L link to publisher link to intranet
		Galenic Lab-on-a-Chip concept for lipid nanocapsules production Rolley N, Bonnin M, Lefebvre G, Verron D , Bargiel S, Robert L, Riou J, Simonsson C, Bizien T, Gimel J-C, Benoit J-P, Brotons G & Calvignac B link to publisher link to intranet
		Polymer-free hydrogel made of lipid nanocapsules, as a local drug delivery platform Pitorre M, Gazaille C, Le Thuy Trang Pham, Frankova K, Bejaud J, Lautram N, Riou J, Perrot R, Genevieve F, Moal V, Benoit JP & Bastiat G link to publisher link to intranet
		Characterization of Biological Material Adsorption to the Surface of Nanoparticles without a Prior Separation Step: a Case Study of Glioblastoma-Targeting Peptide and Lipid Nanocapsules Gazaille C, Sicot M, Akiki M, Lautram N, Dupont A, Saulnier P, Eyer J & Bastiat G link to publisher link to intranet
		A new method to prepare microparticles based on an Aqueous Two-Phase system (ATPS), without organic solvents Dumas F, Benoit JP, Saulnier P & Roger E link to publisher link to intranet
MDPI-Cancers		Ferrocifen Loaded Lipid Nanocapsules: A Promising Anticancer Medication against Multidrug Resistant Tumors Idlas P, Lepeltier E, Jaouen G & Passirani C link to publisher link to intranet
		Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway Sana E , Zeeshan M , Ain QU, Khan AU, Hussain I, Khan S, Lepeltier E & Ali H link to publisher link to intranet
		New In Vitro Coculture Model for Evaluating Intestinal Absorption of Different Lipid Nanocapsules Kaeokhamloed N, Roger E, Béjaud J, Lautram N, Manero F, Perrot R, Abbara C, Briet M and Legeay S link to publisher link to intranet
		Specificity of pharmacokinetic modeling of nanomedicines LebretonV, Legeay S, Saulnier P & Lagarce F link to publisher link to intranet
MDPI-Cancers		pH-Responsive Lipid Nanocapsules: A Promising Strategy for Improved Resistant Melanoma Cell Internalization Pautu V, Lepletier E, MellingerA, Riou J, Debuigne A, Jérôme C, Clère N & Passirani C link to publisher link to intranet
		Effects of physical activity on cell-to-cell communication during type 2 diabetes: A focus on miRNA signaling Foudi N & Legeay S link to publisher link to intranet
		Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody – Bevacizumab – and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies María Lina Formica, Samuel Legeay, Jérôme Bejaud, Guillermo Gabriel Montich, Gabriela Verónica Ullio Gamboa, Jean-Pierre Benoit, Santiago Daniel Palma link to publisher link to intranet
		Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target Lucas Treps, Sébastien Faure, Nicolas Clere link to publisher link to intranet
		Dietary sodium restriction sex specifically impairs endothelial function via mineralocorticoid receptor-dependent reduction in NO bioavailability in Balb/C mice Faulkner JL, Harwood D, Kennard S, Antonova G, Clere N and Belin de Chantemele EJ link to publisher link to intranet
		p722 ferrocifen loaded lipid nanocapsules improve survival of murine xenografted-melanoma via a potentiation of apoptosis and an activation of CD8⁺ T lymphocytes Solene Topin-Ruiz, Adelie Mellinger, Elise Lepeltier, Clara Bourreau, Juliette Fouillet, Jeremie Riou, Gerard Jaouen, Ludovic Martin, Catherine Passirani, Nicolas Clere link to publisher link to intranet
		Neuroprotective effects of Myricetin on Epoxiconazole-induced toxicity in F98 cells Hiba Hamdi, Salwa Abid-Essefi, Joel Eyer link to publisher link to intranet
		“All in One” Epoxy-Based Microfluidic Chips at Your Fingertips Simon Raffy, Etienne Palleau, Brice Calvignac, Guillaume Brotons, Guillaume Lefebvre, Nicolas Rolley, Sébastien Teychene, Bernard Viguier, Sara Castaño Cerezo, Gilles Truan, and Laurence Ressier link to publisher link to intranet
		Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines Abdallah Ladaycia, Brigitta Loretz, Catherine Passirani, Claus-Michael Lehr, Elise Lepeltier link to publisher link to intranet
		SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics Edurne Luque-Michel, Laurent Lemaire & Maria J. Blanco-Prieto link to publisher link to intranet

Granting agencies