fr | en
Micro et Nanomédecines translationnelles

Welcome on MINT homepage

The MINT laboratory is funded by the University of Angers, as well as the French National Institute of Health and Medical Research (INSERM) and The French National Center for Scientific Research (CNRS). Located within the Hospital Facility, the MINT laboratory consists of 40 researchers and PhD students with expertise in diverse fields including; colloids and interfaces physical-chemistry; galenic; chemical engineering for pharmaceutical formulation; biological research; and imaging. All our research is focused on the design of nano- and micro-scaled vectors for the delivery of therapeutics (encompassing proteins, anti-cancer drugs, DNA, SiRNA, mRNA, etc.) and/or imaging probes.

Follow us on Twitter 

News

Academic training

 

Master 2 NanoPharma Nanomedicines and Pharmaceutical R&D

 

European Mundus Joint master Degree " Nanomedicine for drug delivery"

Recently published

 

 

MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

Hussein H Genedy , Paul Humbert Bilel Laoulaou, Brian Le Moal , Marion Fusellier Catherine Passirani , Catherine Le Visage , Jérôme Guicheux Élise Lepeltier  & Johann Clouet 

link to publisher               link to intranet

 

Caliper, contrast enhanced-ultrasound or laser speckle contrast imaging: Techniques to follow mice melanoma growth

Adélie Mellinger, Jeanne Hersant, Clara Bourreau, Simon Lecoq, Eva Deveze, Nicolas Clere & Samir Henni

link to publisher               link to intranet

 

Electrochemical Nucleic Acid Biosensor on a Microfluidic Chip to Understand the Coupling between Electrochemistry and Microfluidics

Marie-Charlotte Horny, MartinaFreisa, ClairePoujouly, Pedro Gonzalez-Losada, Jeremy Le Gall, Thi-Hong-Nhung Dinh, David Bouville, Isabelle Le Potier,Antoine Pallandre and Jean Gamby

link to publisher               link to intranet

 

Diversely substituted poly(N-vinyl amide) derivates towards non-toxic, stealth and pH-responsive lipid nanocapsules

F. Toussaint, E. Lepeltier, F. Franconi, V Pautu, C Jérôme, C. Passirani & A Debuigne

link to publisher               link to intranet

 

Investigating the functionalization of liposomes with NFL-TBS. 40-63 peptides as a promising drug delivery system

M-A Jourdain, A. Dupont, N. Lautram & J. eyer 

link to publisher               link to intranet 

 

The use of liposomes functionalized with the NFL-TBS.40–63 peptide as a targeting agent to cross the in vitro blood–brain barrier and target glioblastoma cells

Adélie Mellinger, Larissa J. Lubitz, Claire Gazaille, Gero Leneweit, Guillaume Bastiat, Claire Lépinoux-Chambaud & Joel Eyer

link to publisher               link to intranet 

 

Evidence of residual micellar structures in a lipid nanocapsule dispersion. A multi-technique approach

Emilie Roger, Florence Franconi, Tran Anh Thu Do, Carl Simonsson, Benjamin Siegler, Rodolphe Perrot, Patrick Saulnier, Jean-Christophe Gimel

link to publisher               link to intranet 

 

Contact angle of ethanol, water, and their mixtures on stainless steel surfaces in dense carbon dioxide
Aymeric Fabien, Guillaume Lefebvre, Elisabeth Badens, Brice Calvignac, Damien Chaudanson, Alain Ranguis, Christelle Crampon

link to publisher               link to intranet 

 

3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
J. Bronsard, C. Savary, J. Massart, R. Viel, L. Moutaux, D. Catheline, V. Rioux, B. Clement , A. Corlu , B. Fromenty , P.J. Ferron

link to publisher               link to intranet 

 

Protein corona formation on lipidic nanocapsules: Influence of the interfacial PEG repartition

Vincent Lebreton, Samuel Legeay, Anastasiia Vasylaki, Fredéric Lagarce, Patrick Saulnier

link to publisher               link to intranet 

 

 

Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel

Claire Gazaille , Elia Bozzato, Neda Madadian-Bozorg, Adélie MellingerMarion Sicot, Umer Farooq, Patrick SaulnierJoël Eyer, Véronique Préat, Nicolas Bertrand, Guillaume Bastiat 

link to publisher        link to intranet

 

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Mickael Lehr & Claudio J Salomon

link to publisher        link to intranet

 

Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies

Cécile DoualleJulien GoujuYousra Nouari, Méline Wery, Clélia Guittonneau, Philippe Codron, Audrey Rousseau, Patrick SaulnierJoël Eyer, Franck Letournel

 

link to publisher        link to intranet

 

Physicochemical Characterization of Ferrocifen Lipid Nanocapsules: Customized Drug Delivery Systems Guided by the Molecular Structure

Pierre Idlas, Elise Lepeltier, Guillaume Bastiat, Pascal Pigeon, Michael J. McGlinchey, Nolwenn Lautram, Anne Vessières, Gerard Jaouen, and Catherine Passirani

link to publisher        link to intranet

 

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

Clara Bourreau, Lucas Treps, Sébastien Faure, Delphine Fradin & nicolas Clère

link to publisher        link to intranet

 

Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

H. Alnemeh-Al Ali, A. Griveau, F. Artzner, A. Dupont, N. Lautram, M.A. Jourdain & J. Eyer

link to publisher        link to intranet

 

Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells
Imen Graiet,
Hiba Hamdi, Salwa Abid-Essefi & J Eyer

link to publisher        link to intranet

 

Pharmacokinetics of intact lipid nanocapsules using new quantitative FRET technique

Lebreton V, Kaeokhamloed N, Vasylaki A, Hilairet G, Mellinger A, Béjaud J, Saulnier P,  Lagarce F, Gattacceca F, Legeay S &  Roger E

link to publisher        link to intranet

 

Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules

A. Griveau, H. Alnemeh-Al Ali, M.A. Jourdain, A. Dupont, J. Eyer

link to publisher        link to intranet

 

Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells.

Griveau A, Arib C, Spadavecchia J, Eyer J.

link to publisher        link to intranet

 

Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma

Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D & Passirani C

link to publisher        link to intranet

 

Cell penetrating peptide (CPP) gold(iii) – complex – bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications

Arib C, Griveau A, Eyer J & Spadavecchia J

link to publisher        link to intranet     full text

 

Reactive precipitation of vaterite calcium carbonate microspheres insupercritical carbon dioxide-water dispersion by microfluidics

Legout P, Lefebvre G, Bonnin M, Gimel JC, Benyahia L, Gibaud A, Marre S, Simonsson C, Wang S, Colombani O  & Calvignac B

link to publisher        link to intranet

Granting agencies

 

                                     

Scroll